Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Giştîkirî Akût
Pustulosis Exanthematous Giştîkirî Akût (Acute generalized exanthematous pustulosis) (AGEP) reaksiyonên çermê kêm e ku di 90 % bûyeran de bi rêveberiya dermanan ve girêdayî ye. Pustulosis Exanthematous Giştîkirî Akût (Acute generalized exanthematous pustulosis) bi rijeyanên çermê nişka ve ku di navînî pênc rojan piştî destpêkirina dermanek xuya dibin, tê destnîşan kirin. Ev rijeyan pustûl in, ango rijandina çermê sor a piçûk, spî an sor, ku tê de maddeya ewr an purul (pişk) heye. Birînên çerm bi gelemperî di nav 1‑3 rojan de piştî rawestandina dermanê sûcdar çareser dibin.
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Birînên berbelav ên bi erythema û pustules ji nîşanê ve xuya dibin.
relevance score : -100.0%
ReferencesAcute generalized exanthematous pustulosis (AGEP) reaksiyonekê çermî ye ku li ser bingehekê çermê sor bi pêlên piçûk û tije pus tê nîşankirin. Ew bi gelemperî di dema ku kesek dermanên wek antîbiyotîk digire, û zû li laş belav dibe. Piştî rawestandina dermanê, nîşanên bi gelemperî di nav du hefteyan de xuya dibin, û bi gelemperî hin rijandina çerm dihêle. Her çend bi gelemperî ne ciddî ne û bi çerm re sînordar in, rewşên giran dikarin bi reaksiyonên çermî yên giran wekî Stevens-Johnson syndrome an toxic epidermal necrolysis re têkilî bixin. Dermankirin di serê de lênihêrîna piştgirî ye, û pêşbîniya ji bo çareseriya tam a nexweşiyê bi gelemperî xweş e.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Zilamekî 76 salî ji ber ku çermê wî di van du rojên dawî de guherîbû hat odeya lezgîn. Bijîjkan li ser qurm û dest û lingên wî deqên sor û deverên bilindkirî dîtin. Her ku dem derbas dibû, van pêçan li hev diciviyan, û wî di nav deverên sor de qulên mîna pizîkê çêdikirin. Testan jimareya şaneyên xwînê yên spî bi gelek celebek bi navê neutrofîl re, û asta C-reactive protein zêde kirin nîşan dan.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
